Polyclonal Antibody to Luteinizing Hormone (LH) Rattus norvegicus (Rat) Polyclonal antibody

ICSH; Lutropin; Interstitial Cell Stimulating Hormone

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Overview
Properties
  • SourcePolyclonal antibody preparation, Host Rabbit
  • Ig Type IgG, Potency n/a
  • PurificationAntigen-specific affinity chromatography followed by Protein A affinity chromatography
  • LabelNone
  • Immunogen RPA441Ra01-Recombinant Luteinizing Hormone (LH)
  • Buffer FormulationPBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
  • TraitsLiquid, Concentration 0.5mg/ml
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  • Polyclonal Antibody to Luteinizing Hormone (LH) Packages (Simulation)
  • Polyclonal Antibody to Luteinizing Hormone (LH) Packages (Simulation)
  • Polyclonal Antibody to Luteinizing Hormone (LH) Used in DAB staining on fromalin fixed paraffin-embedded Kidney tissue
  • PAA441Ra01.jpg Figure. Western Blot; Sample: Recombinant LH, Rat.
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Specifity

The antibody is a rabbit polyclonal antibody raised against LH. It has been selected for its ability to recognize LH in immunohistochemical staining and western blotting.

Usage

Western blotting: 0.01-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

Storage

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Organism Species More: Homo sapiens (Human), Mus musculus (Mouse)

Giveaways

Citations

  • Effects of genistein and estrogen receptor subtype-specific agonists in ArKO mice following different administration routes.PubMed: 19686804
  • Studies of the pharmacology of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol, a synthetic anti-inflammatory androstene Ijcem: IJCEM1102004
  • PPARγ co-activator-1α co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosteronePubMed: 21108604
  • Effects of genistein and estrogen receptor subtype-specific agonists in ArKO mice following different administration routesScienceDirect: S0303720709004043
  • Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspringPubMed: 23314658
  • Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic ratsExcli: Source
  • Central effects of camphor on GnRH and sexual hormones in male ratPubmed: 24551777
  • Inhibitory effects of mitotane on viability and secretory activity in mouse gonadotroph cell linesPubmed: 24486453
  • Effects of Tadalafil on Hemorrhagic Cystitis and Testicular Dysfunction Induced by Cyclophosphamide in RatsPubmed: 24051982
  • Nanocomposites of bio-based hyperbranched polyurethane/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissue engineeringRsc: Source
  • The effects of long-term exposure to a 2450 MHz electromagnetic field on growth and pubertal development in female Wistar ratsInformahealthcare: Source
  • Piper longum hexane fraction induces infertility by modulation of inflammatory mediators and gonadotropin insufficiency in female ratsIjppsjournal: Source
  • Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesisScienceDirect: S0006291X14001843
  • Carbamazepine-exposure during gestation and lactation affects pubertal onset and spermatic parameters in male pubertal offspringPubmed:24126190
  • Quercetin supplementation restores testicular function and augments germ cell survival in the estrogenized ratsPubmed:24316378
  • Protective effects of Eugenia jambolana extract versus N-acetyl cysteine against cisplatin-induced damage in rat testisPubmed:24576220
  • Perfluorooctane sulfonate effects on the reproductive axis in adult male ratsPubmed:25171141
  • Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertilityPubmed:25505846
  • Apoptosis in testicular tissue of rats after vasectomy: evaluation of eNOS, iNOS immunoreactivities and the effects of ozone therapyTurkishjournalofurology:Source
  • Protective effects of Eugenia jambolana extract versus N‐acetyl cysteine against cisplatin‐induced damage in rat testisPubMed: 24576220
  • The effect of R-(-)-deprenyl administration on reproductive parameters of rat malesPubMed: 25725114
  • Dose‐and time‐dependent effects of Garcinia kola seed extract on sexual behaviour and reproductive parameters in male Wistar ratsPubMed: 26123866
  • Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female ratsPubMed: 26476359
  • Maternal High-Fat Diet Induced Loss of Fetal Oocytes Is Associated with Compromised Follicle Growth in Adult Rat OffspringPubmed:26962114
  • Dose- and time-dependent effects of Garcinia kola seed extract on sexual behaviour and reproductiveparameters in male Wistar rats.Pubmed:26123866
  • Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in MicePubmed:26771609
  • A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in DendritogenesisPubmed:26977770
  • Molecular characterization of insulin resistance and glycolytic metabolism in the rat uteruspubmed:27461373
  • Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome.pubmed:28336389
  • Environmental exposure to polycyclic aromatic hydrocarbons (PAHs): The correlation with and impact on reproductive hormones in umbilical cord serum.pubmed:27838061
  • Exposure of pregnant mice to perfluorobutanesulfonate causes hypothyroxinemia and developmental abnormalities in female offspringpubmed:27803384
  • Effects of treatment with Hypoxis hemerocallidea extract on sexual behaviour and reproductiveparameters in male rats.pubmed:28000943
  • Maternal High-Fat Diet-Induced Loss of Fetal Oocytes Is Associated with Compromised Follicle Growth in Adult Rat Offspring.pubmed:26962114
  • Impact of uteroplacental insufficiency on postnatal rat male gonad.pubmed:27885054
  • New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency.pubmed:28232269
  • Pyrethroid Insecticide Cypermethrin Accelerates Pubertal Onset in Male Mice via Disrupting Hypothalamic-Pituitary-Gonadal Axispubmed:28731686
  • Development of New Gonadotropin-Releasing Hormone-Modified Dendrimer Platforms with Direct Antiproliferative and Gonadotropin Releasing Activitypubmed:28958147
  • Pyrethroid Insecticide Cypermethrin Modulates Gonadotropin Synthesis via Calcium Homeostasis and ERK1/2 Signaling in LbT2 Mouse Pituitary Cellspubmed:29149324
  • Vitamin D deficiency impairs testicular development and spermatogenesis in micepubmed:28655646
  • Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis.pubmed:28578315
  • High sensitivity of testicular function to titanium nanoparticlespubmed:28496042
  • The Combination of icariin and constrained dynamic loading stimulation attenuates bone loss in ovariectomy‐induced osteoporotic micepubmed:29058779
  • Transdermal Delivery of Luteinizing Hormone-releasing Hormone with Chitosan Microneedles: A Promising Tool for Androgen Deprivation Therapypubmed:29187457
  • Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathwaypubmed:29020999
  • Effect of controlled ovarian hyperstimulation on puberty and estrus in mice offspringpubmed:28687593
  • Atorvastatin decreases steroid production in H295R cells and in major endocrine tissues of male ratsPubmed:29574565
  • Vasorin: a newly identified regulator of ovarian folliculogenesisPubmed:29259033
  • The role of mesenchymal stem cells in chemotherapy-induced gonadotoxicityPubmed:30021657
  • Prenatal exposure to polychlorinated biphenyl and umbilical cord hormones and birth outcomes in an island populationPubmed:29525625
  • Impact of Perfluorooctane Sulfonate on Reproductive Ability of Female Mice through Suppression of Estrogen Receptor a-Activated Kisspeptin Neurons10.1093:toxsci
  • Impact of Triclosan on Female Reproduction through Reducing Thyroid Hormones to Suppress Hypothalamic Kisspeptin Neurons in MicePubmed:29403355
  • Maternal nutrient restriction impairs young adult offspring ovarian signaling resulting in reproductive dysfunction and follicle lossPubmed:29351580
  • DHEA-induced ovarian hyperfibrosis is mediated by TGF-β signaling pathwayPubmed:29321035
  • Eicosapentaenoic Acid Improves Polycystic Ovary Syndrome in Rats via Sterol Regulatory Element-Binding Protein 1 (SREBP-1)/Toll-Like Receptor 4 (TLR4) …Pubmed:29627845
  • Palladium nanoparticle effects on endocrine reproductive system of female ratsPubmed:29405765
  • A Pex13 knockout in germ cells induces a spermatogenic arrestvolltexte:2018/8921/
  • Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neuronsDoi: 10.1016/j.biopha.2018.08.135
  • 基因敲除损伤小鼠睾丸睾酮产生与生精功能
  • Effects of feeding frequency during lactation in primiparous sows on reproduction performance and diurnal rhythm of endocrine profiles at the weaning-to-ovulation …
  • Protective Effects of Uncultured Adipose‐Derived Stromal Vascular Fraction on Testicular Injury Induced by Torsion‐Detorsion in RatsPubmed: 30569668
  • Uterine progesterone signaling is a target for metformin therapy in polycystic ovary syndromePubmed: 29535146
  • Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary
  • Organic Zn and Cu interaction impact on sexual behaviour, semen characteristics, hormones and spermatozoal gene expression in bucks (Capra hircus)
  • The therapeutic potential of amifostine on cyclophosphamide-induced testicular dysfunction in rats: An experimental study.
  • Sperm parameters quality and reproductive effects of methanolic extract of Alchornea cordifolia leaves on senescent male ratsPubmed: 31353623
  • Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinasePubmed: 31722718
  • Exposure of adult mice to perfluorobutanesulfonate impacts ovarian functions through hypothyroxinemia leading to down-regulation of Akt-mTOR signalingPubmed: 31809938
  • Effect of DHT-Induced Hyperandrogenism on the Pro-Inflammatory Cytokines in a Rat Model of Polycystic Ovary MorphologyPubmed: 32120970
  • Prenatal exposure of female mice to perfluorononanoic acid delays pubertal activation of the reproductive endocrine axis through enhanced hepatic FGF21 …Pubmed: 33131727
  • Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance …Pubmed: 33109277
  • MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistancePubmed: 32757043
  • Electroacupuncture alleviates polycystic ovary syndrome-like symptoms through improving insulin resistance, mitochondrial dysfunction, and endoplasmic …Pubmed: 32698821
  • Composition of Royal Jelly (RJ) and Its Anti-Androgenic Effect on Reproductive Parameters in a Polycystic Ovarian Syndrome (PCOS) Animal ModelPubmed: 32517356
  • N, N-Dimethylacetamide, an FDA approved excipient, acts post-meiotically to impair spermatogenesis and cause infertility in ratsPubmed: 32447106
  • Chronic exposure to low dose of bisphenol A causes follicular atresia by inhibiting kisspeptin neurons in anteroventral periventricular nucleus in female micePubmed: 32407858
  • Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic …Pubmed: 31648559
  • Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat StressPubmed: 32685488
  • Evaluation for adverse effects of InP/ZnS quantum dots on the in vitro cultured oocytes of mice
  • Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS
  • Hemin Ameliorated Letrozole-Induced Polycystic Ovary Syndrome: A Forward Step for Better Management
  • Zihuai recipe alleviates cyclophosphamide-induced diminished ovarian reserve via suppressing PI3K/AKT-mediated apoptosis33422655
  • The Effects of Zinc Methionine on Reproductive and Thyroid Hormones in Rats with Polycystic Ovarian Syndrome33457340
  • Diabetes Type 1 Negatively Influences Leydig Cell Function in Rats, Which is Partially Reversible By Insulin Treatment33507237
  • BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-¦ÊB pathways in aging mice induced by D-galactose33508368
  • Exposure to the bromodomain inhibitor N-methyl pyrrolidone blocks spermatogenesis in a hormonal and non-hormonal fashion33965371
  • Effects of increasing intake of soybean oil on synthesis of testosterone in Leydig cells34039393
  • Tribulus terrestris Efficacy and Safety Concerns in Diabetes and Erectile Dysfunction, Assessed in an Experimental Model33920217
  • Lipoamino Acid-Modified GnRH Analogs with Receptor-Mediated Antiproliferative Activity in Prostate and Ovarian Cancer Cells
  • Regulation of Uterine Function During Estrous Cycle, Anestrus Phase and Pregnancy by Steroids in Red Deer (Cervus elaphus L.)
  • Chronic Exposure to Perfluorohexane Sulfonate Leads to a Reproduction Deficit by Suppressing Hypothalamic Kisspeptin Expression in Mice
  • Human and animal fertility studies in cystinosis reveal signs for obstructive azoospermia, a disruptive blood‐testis barrier and a subtherapeutic effect of cysteamine in …34494673
  • Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion34610361
  • Polyamine metabolism links gut microbiota and testicular dysfunction34758869
  • Zika virus infection in the ovary induces continuously elevated progesterone level and compromises conception in interferon α/β receptor-deficient mice34730391
  • METTL3-mediated mRNA N6-methyladenosine is required for oocyte and follicle development in mice34689175
  • Superior effect of broccoli methanolic extract on control of oxidative damage of sperm cryopreservation and reproductive performance in rats: A comparison with …Pubmed:35063921
  • Yogurt Enriched with Inulin Ameliorated Reproductive Functions and Regulated Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome MicePubmed:35057459
  • Exposure to multiple pyrethroid insecticides affects ovarian follicular development via modifying microRNA expressionPubmed:35276145
  • Constitutional delay of growth and puberty in female mice is induced by circadian rhythm disruption in uteroPubmed:35679725
  • A promising animal model for Polycystic Ovary Syndrome: Borderline Hypertensive Rats

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