Myeloproliferative Leukemia Virus Oncogene (MPL)

CD110; C-MPL; MPLV; TPOR; Thrombopoietin Receptor; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl
Myeloproliferative Leukemia Virus Oncogene (MPL)
Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.
Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
  • Protein RPB468Ra01Recombinant Myeloproliferative Leukemia Virus Oncogene (MPL)Customize
  • AntibodyPAB468Ra01Polyclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL)Customize
  • AntibodyMAB468Ra21Monoclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL)Customize
  • Assay KitSEB468RaELISA Kit for Myeloproliferative Leukemia Virus Oncogene (MPL)Customize
  • Assay KitSCB468RaCLIA Kit for Myeloproliferative Leukemia Virus Oncogene (MPL)Customize
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