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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Myeloproliferative Leukemia Virus Oncogene (MPL)
CD110; C-MPL; MPLV; TPOR; Thrombopoietin Receptor
Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.
Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPB468Hu01 Recombinant Myeloproliferative Leukemia Virus Oncogene (MPL) In Stock
Antibodies PAB468Hu01 Polyclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL) In Stock
MAB468Hu21 Monoclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL) Customize
Assay Kits SEB468Hu ELISA Kit for Myeloproliferative Leukemia Virus Oncogene (MPL) Customize
SCB468Hu CLIA Kit for Myeloproliferative Leukemia Virus Oncogene (MPL) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPB468Mu01 Recombinant Myeloproliferative Leukemia Virus Oncogene (MPL) In Stock
Antibodies PAB468Mu01 Polyclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL) In Stock
MAB468Mu21 Monoclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL) Customize
Assay Kits SEB468Mu ELISA Kit for Myeloproliferative Leukemia Virus Oncogene (MPL) Customize
SCB468Mu CLIA Kit for Myeloproliferative Leukemia Virus Oncogene (MPL) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPB468Ra01 Recombinant Myeloproliferative Leukemia Virus Oncogene (MPL) Customize
Antibodies PAB468Ra01 Polyclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL) Customize
MAB468Ra21 Monoclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL) Customize
Assay Kits SEB468Ra ELISA Kit for Myeloproliferative Leukemia Virus Oncogene (MPL) Customize
SCB468Ra CLIA Kit for Myeloproliferative Leukemia Virus Oncogene (MPL) Customize