Recombinant Interleukin 35 (IL35) Homo sapiens (Human) Recombinant protein

  • Product No.RPC008Hu01
  • Organism SpeciesHomo sapiens (Human) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular Locationn/a
  • Predicted Molecular Mass49.0kDa
  • Accurate Molecular Massn/a(Analysis of differences refer to the manual)
  • Residues & TagsThe IL35 complex composed of IL27B subunit (Arg21-Lys229) and the mature form of human IL12A (Arg23-Ser219) linked by a polypeptide linker (GGGGS)3 with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder
  • Purity> 95%
  • Isoelectric Point8.7
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 1g In stock
  • FOB US$ 186.00 FREE TRIAL US$ 464.00 FREE TRIAL US$ 928.00 FREE TRIAL US$ 2,784.00 FREE TRIAL US$ 69,600.00 FREE TRIAL
  • Quantity
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  • Recombinant Interleukin 35 (IL35) Packages (Simulation)
  • Recombinant Interleukin 35 (IL35) Packages (Simulation)
  • RPC008Hu01.jpg SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

SEQUENCE

USAGE

Reconstitute in PBS or others.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Citations

  • Oncology Letters Aberrant expression of Treg-associated cytokine IL-35 along with IL-10 and TGF-β in acute myeloid leukemia.PubMed: 22783403
  • Journal of Maternal-Fetal and Neonatal MedicinePlasma IL-17, IL-35, interferon-γ, SOCS3 and TGF-β levels in pregnant women with preeclampsia, and their relation with severity of diseasePubmed: 24175856
  • Journal of Reproductive ImmunologyWhat is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility?Pubmed: 24368037
  • Human ImmunologyThe imbalanced profile and clinical significance of T helper associated cytokines in bone marrow microenvironment of the patients with acute myeloid leukemiaScienceDirect: S0198885913005776
  • Folia Biologica (Praha)Gene Expression of Subunits of the IL-12 Family Cytokines in moDCs Derived In Vitro from the Cord Blood of Children of Healthy and Allergic MothersPubmed:24785110
  • Molecular Medicine ReportsFunction of interleukin?17 and ?35 in the blood of patients with hepatitis B?related liver cirrhosisPubmed:25323532
  • Rom J Morphol Embryol.The regular distribution and expression pattern of immunosuppressive cytokine IL-35 in mouse uterus during early pregnancyPubmed:25611266
  • Journal of ImmunotherapyWogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor ImmunityPubMed: 25962106
  • PLOS ONEInterleukin 35 Synovial Fluid Levels Are Associated with Disease Activity of Rheumatoid ArthritisPubMed: 26204444
  • Rheumatology (Oxford)Interleukin-35 is upregulated in systemic sclerosis and its serum levels are associated with early diseasePubMed: 26231346
  • CytokineAnti-inflammatory effects of interleukin-35 in acquired aplastic anemiaPubMed: 26282938
  • J Biol ChemInterleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 PathwayPubMed: 26085094
  • Br J HaematolInterleukin 35 may contribute to the loss of immunological self‐tolerance in patients with primary immune thrombocytopeniaPubMed: 25640666
  • Autoimmunity ReviewsNew insights into immune mechanisms underlying response to Rituximab in patients with membranous nephropathy: A prospective study and a review of the literaturePubmed:26876383
  • Clinical researchIncreased plasma concentrations of interleukin 35 in patients with coronary artery diseaseJournal:-19
  • Clinical RheumatologyThe clinical utility of serum IL-35 in patients with polymyositis and dermatomyositispubmed:27502600
  • Respiratory MedicineEnhanced LPS-induced activation of IL-27 signalling in sarcoidosispubmed:27492538
  • International Journal of Molecular MedicineEffects of an intravitreal injection of interleukin-35-expressing plasmid on pro-inflammatory andanti-inflammatory cytokines.pubmed:27460435
  • 上海口腔医学IL-35在牙周炎及口腔扁平苔藓中的表达及相关性分析QK:98604X

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