Recombinant Interleukin 6 (IL6)Homo sapiens (Human)Recombinant protein

MGI2-A; MGI2A; HGF; BSF2; HSF; IFNB2; B-Cell Stimulatory Factor-2; Hybridoma/Plasmacytoma Growth Factor; Hepatocyte Stimulating Factor; Cytotoxic T-Cell Differentiation Factor

  • Product No.RPA079Hu01
  • Organism SpeciesHomo sapiens (Human)Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted.
  • Predicted Molecular Mass47.1kDa
  • Accurate Molecular Massn/a(Analysis of differences refer to the manual)
  • Residues & TagsPro29~Met212 (Accession # P05231) with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • TraitsFreeze-dried powder
  • Purity> 95%
  • Isoelectric Point6.0
  • ApplicationsSDS-PAGE; WB; ELISA; IP.
  • DownloadInstruction Manual
  • UOM10ug50ug200ug1mg1g
  • FOBUS$ 155US$ 388US$ 776US$ 2328US$ 58200
  • Recombinant Interleukin 6 (IL6)Package and Components
  • Recombinant Interleukin 6 (IL6)Package and Components
    • RPA079Hu01.jpgSDS-PAGE
    • CertificateISO9001: 2008, ISO13485: 2003 Registered

    SEQUENCE

    USAGE

    Reconstitute in PBS or others.

    STORAGE

    Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

    STABILITY

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

    Reference

    • Journal of Korean Neurosurgical SocietyNotochordal Cells Influence Gene Expression of Inflammatory Mediators of Annulus Fibrosus Cells in Proinflammatory Cytokines StimulationPubMed: PMC2916142
    • Experimental AnimalsAnti-Inflammatory Effect of Guan-Xin-Er-Hao via the Nuclear Factor-Kappa B Signaling Pathway in Rats with Acute Myocardial InfarctionJstage: source
    • Journal of Translational MedicineLow temperature of radiofrequency ablation at the target sites can facilitate rapid progression of residual hepatic VX2 carcinomaBioMed: 14795876
    • IUBMB LIFE Genetic repression of mouse VEGF expression regulates coagulation cascade.PubMed: 21086498
    • Not availableAnalysis of genetic markers for cardiovascular disorders in a portuguese population with familial hypercholesterolemiaUniversi: 49434630
    • Acta OtolaryngolSerial cytokine levels during wound healing in rabbit maxillary sinus mucosaPubMed: 19958244
    • The EMBO Journal Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in miceNature: 2011277
    • Reproductive BioMedicine OnlineSoluble BAFF-R produced by decidual stromal cells plays an inhibitory role in monocytes and macrophages ScienceDirect: S1472648312001484
    • CarcinogenesisThe association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancerOxfordJournals: source
    • Diabetes Research and Clinical PracticePlasma SFRP5 levels are decreased in Chinese subjects with obesity and type 2 diabetes and negatively correlated with parameters of insulin resistancePubMed: 23290274
    • BoneSynthesis and inflammatory response of a novel silk fibroin scaffold containing BMP7 adenovirus for bone regenerationPubMed: 22796416
    • Heart and Education in HeartThe change of serum level of pigment epithelium-derived factor in coronary heart diseaseBmj: Source
    • Journal of Surgical ResearchEnhanced tumor growth after portal vein embolization in a rabbit tumor modelPubMed: 23149224
    • NanomedicineEfficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatformPubMed: 23394132
    • PLoS OneNew Method to Isolate and Culture Rat Kupffer CellsPubMed: PMC3743898
    • PLoS OneRecombinant Adiponectin Ameliorates Liver Ischemia Reperfusion Injury via Activating the AMPK/eNOS PathwayPubMed: PMC3676360
    • PLoS One.Molecular Effects of Doxycycline Treatment on Pterygium as Revealed by Massive Transcriptome SequencingPubMed: PMC3378547
    • Oncology Reports A bone-seeking clone exhibits different biological properties from the ACHN parental human renal cell carcinoma in vivo and in vitroPubMed: PMC3583590
    • Experimental and Therapeutic MedicineShuangtengbitong tincture treatment of collagen-induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κBPubMed: PMC3570159
    • 6th International Scientific Interdisciplinary Conference (ISIC)Inflammation influence on the formation of endothelial dysfunction in hypertensive patients caused by obesityKnmu: Source
    • Lower Urinary Tract SymptomsEffects of Saw Palmetto Extract on Urodynamic Parameters, Bladder Muscarinic and Purinergic Receptors and Urinary Cytokines in Rats with Cyclophosphamide-Induced CystitisOnlinelibrary: luts.12015
    • Polish Journal of Veterinary SciencesThe effect of different dietary levels of vitamin E and selenium on antioxidant status and immunological markers in serum of laying hensPubmed: 23971202
    • Journal of natural remediesIxora coccinea down Regulate the Inflammation-Associated Prostaglandins (PGE-2), Nitric Oxide (NO) and Cytokines Production in LPS-Stimulated RAW 264.7 MacrophageJnronline: Source
    • The Veterinary JournalMonocyte chemotactic protein-1 and other inflammatory parameters in Bernese Mountain dogs with disseminated histiocytic sarcomaPubmed: 23992872
    • Archives of Medical ResearchEffect of α-Linolenic Acid on Streptozotocin-induced Diabetic Retinopathy Indices In VivoPubmed: 24120388
    • Glob J Health Sci. Inflammatory markers and haptoglobin polymorphism in Saudi with non-insulin-dependent diabetes mellitus.Pubmed: 23283045
    • Inflamm Res.Intracranial injection of recombinant stromal-derived factor-1 alpha (SDF-1α) attenuates traumatic brain injury in rats.Pubmed: 24352531
    • Molecules. Identification of compounds from the water soluble extract of Cinnamomum cassia barks and their inhibitory effects against high-glucose-induced mesangial cells.Pubmed: 24013407
    • PLoS One. Megakaryocytic leukemia 1 (MKL1) regulates hypoxia induced pulmonary hypertension in rats.Pubmed: 24647044
    • J Surg Res. Immunogenic alteration in laparoscopic common bile duct exploration.Pubmed: 24239148
    • BMC anesthesiologyRepeated open endotracheal suctioning causes gradual desaturation but does not exacerbate lung injury compared to closed endotracheal suctioning in a rabbit model of ARDS.Pubmed: 24308643
    • Physiological ResearchBudesonide added to modified porcine surfactant Curosurf may additionally improve the lung functions in meconium aspiration syndrome.Pubmed: 2432969
    • Journal of EthnopharmacologyBioactive compounds from Cornus officinalis fruits and their effects on diabetic nephropathyScienceDirect: S0378874114002414
    • PLoS One.HIF-1α Is Essential for Effective PMN Bacterial Killing, Antimicrobial Peptide Production and Apoptosis in Pseudomonas aeruginosa KeratitisPlos: Source
    • Journal of Materials Chemistry BNanocomposites of bio-based hyperbranched polyurethane/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissue engineeringRsc: Source
    • Biosensors and BioelectronicsA new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structureScienceDirect: S0956566314001924
    •  Journal of Pharmaceutical Sciences and PharmacologyAnti-inflammatory Effect of Euphorbia hirta Leaf Extract in Rats and Modulation of Inflammation-Associated Prostaglandins (PGE-2) and Nitric Oxide (NO) Expression in RAW264.7 MacrophageIngentaconnect: Source
    • Veterinary ResearchImmunosuppression abrogates resistance of young rabbits to Rabbit Haemorrhagic Disease (RHD)Biomedcentral: Source
    • Biochem Biophys Res Commun.Dipeptidyl peptidase-4 inhibitor ameliorates early renal injury through its anti-inflammatory action in a rat model of type 1 diabetesPubmed: 24342619
    • INTERNATIONAL JOURNAL OF MEDICINE AND MEDICAL RESEARCHL-ARGININE, BUT NOT L-NAME PROTECTS AGAINST LIVER INJURY INDUCED BY EXPERIMENTAL ISCHEMIA-REPERFUSIONTdmu:Source
    • Anesthesia &amp; Clinical
ResearchEffect of High Pressure-Volume and Low Pressure-Volume Mechanical Ventilation on Plasma Concentrations of Inflammatory Markers in Horses during General …Org:Source
    • Basic &amp; Clinical Pharmacology &amp; ToxicologyTreatment with Carnitine Enhances Bone Fracture Healing under Osteoporotic and/or Inflammatory ConditionsWiley:Source
    • New Journal of ChemistryBiophysico-chemical interfacial attributes of Fe3O4 decorated MWCNT nanohybrid/bio-based hyperbranched polyurethane nanocomposite: an antibacterial wound healing material with controlled drug release potentialRsc:Source
    • 芦荟大黄素抑制LPS诱导RAW264.7细胞释放炎症因子作用机制研究Docin:Source
    • Evidence-Based Complementary and Alternative MedicineGinsenosides Rg1 from Panax ginseng: A Potential Therapy for Acute Liver Failure Patients?Pubmed:Pmc4241314
    • Pharmacognosy Res.Margaritaria discoidea (Euphorbiaceae) stem bark extract attenuates allergy and Freund&#039;s adjuvant-induced arthritis in rodentsPubmed:Pmc3996754
    • Nucleic Acids Res.MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cellsPubmed:Pmc4176337
    • Int J Chron Obstruct Pulmon Dis. Increased serum levels of lipocalin-1 and-2 in patients with stable chronic obstructive pulmonary diseasePubmed:Pmc4043430
    • PLOS ONEMegakaryocytic Leukemia 1 (MKL1) Regulates Hypoxia Induced Pulmonary Hypertension in RatsPubmed:Pmc3960100
    • Inflamm Res. Intracranial injection of recombinant stromal-derived factor-1 alpha (SDF-1α) attenuates traumatic brain injury in ratsPubmed:24352531
    • InflammationEffects of honokiol on sepsis-induced acute kidney injury in an experimental model of sepsis in ratsPubmed:24531855
    • Biosens Bioelectron. A?new?signal?amplification?strategy?of?photoelectrochemical?immunoassay?for?highly?sensitive?interleukin-6?detection?based?on?TiO2/CdS/CdSe?dual?co-sensitized?structure.Pubmed:24690561
    • Immunology LettersEnhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6Pubmed:24698728
    • J Surg Res.Valproic acid protects septic mice from renal injury by reducing the inflammatory responsePubmed:24948542
    • Inflammation.?Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway.Pubmed:24962643
    • Archives of Oral BiologyHyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Implications in acute and chronic infectionsPubmed:24992577
    • European Review for Medical and Pharmacological SciencesThe anti-inflammatory effects of 1,1 dimethyl-4- phenylpiperazinium (DMPP) compared to dexamethasone in a guinea pig model of ovalbumin induced asthmaPubmed:25070830
    • Inflammation.Oral administration?of?Saccharomyces?boulardii ameliorates carbon tetrachloride-induced liver fibrosis in?rats?via reducing intestinal permeability and modulating gut microbial composition.Pubmed:25227279
    • PLOS ONEBisphenol A Exposure Enhances Atherosclerosis in WHHL RabbitsPubmed:25333893
    • Journal of Dental ResearchNotch Signaling Induces Root Resorption via RANKL and IL-6 from hPDL CellsPubmed:25376720
    • Molecular Medicine ReportsGYY4137, a hydrogen sulfide?releasing molecule, inhibits the inflammatory response by suppressing the activation of nuclear factor?kappa B and mitogen?activated protein kinases in Coxsackie virus B3?infected rat cardiomyocytesPubmed:25377925
    • Life SciencesAdipose tissue regulates hepatic cholesterol metabolism via adiponectinPubmed:25445438
    • Journal of Surgical ResearchUrsolic acid improves survival and attenuates lung injury in septic rats induced by cecal ligation and puncturePubmed:25454976
    • Veterinary ResearchThe innate immune response of equine bronchial epithelial cells is altered by trainingPubmed:25595212
    • Journal of Translational MedicineProtective effects of astaxanthin against ischemia/reperfusion induced renal injury in micePubmed:25623758
    • Molecular Medicine ReportsTanshinone ⅡA attenuates bleomycin-induced pulmonary fibrosis in ratsPubmed:25672255
    • Reproduction in Domestic AnimalsThe Concentrations of Inflammatory Cytokines and Acute‐Phase Proteins in the Peripheral Blood and Uterine Washings in Cows with PyometraPubmed:25704413
    • Journal of Surgical ResearchExogenous carcinoembryonic antigen-related cell adhesion molecule 1 suppresses 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in micePubmed:25724769
    •  International Journal of Clinical and Experimental PathologyPanax notoginseng saponins promote wound repair of anterior cruciate ligament through phosphorylation of PI3K, AKT and ERKPubmed:25755732
    • TheriogenologyInflammatory cytokines and acute-phase proteins concentrations in the peripheral blood and uterus of cows that developed endometritis during early postpartum.Pubmed:25765299
    • Journal of Surgical ResearchPivotal role of mast cell carboxypeptidase A in mediating protection against small intestinal ischemia–reperfusion injury in rats after ischemic preconditioningSciencedirect:S0022480414004909
    • Int J Clin Exp PatholRosiglitazone attenuates renal injury caused by hyperlipidemic pancreatitisPubMed: 26191125
    • Clinical and Experimental Pharmacology and PhysiologyCurcumin alleviates lung injury in diabetic rats by inhibiting nuclear factor‐κB pathwayPubMed: 26111829
    • Mediators of InflammationEffects of Intravenous Injection ofPubMed: 26063970
    • Int J Clin Exp PatholExpression of S100 family proteins in neonatal rats with sepsis and its significancePubMed: 25973048
    • Am J Physiol Heart Circ PhysiolIrisin improves endothelial function in obese mice through the AMPK-eNOS pathwayPubMed: 26371167
    • Biomedical ReportsAuricularia auricularBr: 3
    • Acta Vet ScandSerum IL-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomyPubMed: 26410584
    • Clin Oral InvestigCan apical periodontitis affect serum levels of CRP, IL-2, and IL-6 as well as induce pathological changes in remote organs?PubMed: 26556576
    • Int J Clin Exp PatholEffects of dexmedetomidine on the protection of hyperoxia-induced lung injury in newborn ratsPubMed: 26261523
    • Front PharmacolGlycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in ratsPubMed: 26483688
    • J Clin LipidolPlasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistancePubMed: 26073386
    • Cell Stress ChaperonesSalidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathwaysPubMed: 26577463
    • Life SciBetulin attenuates kidney injury in septic rats through inhibiting TLR4/NF-κB signaling pathwayPubMed: 26656467
    • Asian Pac J Trop MedEffect of SecinH3 on lung injury induced by sepsis of ratsPubMed: 26706678
    • PLOS ONEPenehyclidine Hydrochloride Preconditioning Provides Cardioprotection in a Rat Model of Myocardial Ischemia/Reperfusion InjuryPubMed: 26632817
    • PLOS ONEPlasma HMGB-1 Levels in Subjects with Obesity and Type 2 Diabetes: A Cross-Sectional Study in ChinaPubMed: 26317615
    • Int ImmunopharmacolBetulin attenuates lung and liver injuries in sepsisPubMed: 26644168
    • Journal of the Korean Society for Applied Biological ChemistryAnti-inflammatory effect ofArticle: 10.1007
    • J Histochem CytochemGlycyrrhizic Acid Prevents Sepsis-Induced Acute Lung Injury and Mortality in RatsPubMed: 26385569
    • Acta Cir BrasEffect of remote ischemic preconditioning in the expression of IL-6 and IL-10 in a rat model of liver ischemia-reperfusion injuryPubMed: 26270136
    • veterinary research forumEvaluation of proliferation and cytokines production by mitogen-stimulated bovine peripheral blood mononuclear cellsArticle_14936_6.Html:
    • Anim Reprod Sci.Alteration in peripheral blood concentration of certain pro-inflammatory cytokines in cows developing retention of fetal membranesPubMed: 25851495
    • Front Cell NeurosciPrenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cellsPubMed: 25814933
    • Journal of Medicinal FoodA Standardized Extract ofPubMed: 26501382
    • Clin Exp Pharmacol PhysiolSilymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitroPubMed: 26173462
    • Int J Clin Exp MedBerberine protects vascular endothelial cells in hypertensive ratsPubMed: 26628971
    • Molecular Medicine ReportsEfficacy of coenzyme Q11 in mitigating spinal cord injuryPubMed: 26016719
    • Immunologic ResearchMesenchymal stromal cell-dependent reprogramming of Kupffer cells is mediated by TNF-α and PGE4 and is crucial for liver transplant tolerancePubMed: 25982496
    • Journal of Surgical ResearchCyanidin-3-O-glucoside attenuates acute lung injury in sepsis ratsPubMed: 26152793
    • Life SciencesNeuroprotective effect of allicin in a rat model of acute spinal cord injuryPubMed: 26546416
    • Tumor BiologyHypoxia-induced secretion of IL-18 from adipose-derived mesenchymal stem cell promotes growth and cancer stem cell properties of Burkitt lymphomaPubMed: 26695151
    • Biosens BioelectronUltrasensitive photoelectrochemical immunoassay for CA19-9 detection based on CdSe@ZnS quantum dots sensitized TiO2NWs/Au hybrid structure amplified by quenching effect of Ab2@V2+PubMed: 26433066
    • Hepatology ResearchAmelioration of free fatty acid-induced fatty liver by quercetin-3-O-尾-D-glucuronide through modulation of peroxisome proliferator-activated receptor-alpha/sterol regulatory element-binding protein-1c signalingPubMed: 26190035
    • Experimental and Therapeutic MedicineSignificance of the changes occurring in the levels of interleukins, SOD and MDA in rat pulmonary tissue following exposure to different altitudes and exposure times PubMed: 26622414
    • Медицина и здравоохранениеДИНАМИКА ЦИТОКИНОВОГО ПРОФИЛЯ В ОЦЕНКЕ ЭФФЕКТИВНОСТИ РАЗНЫХ МЕТОДОВ СТИМУЛЯЦИИ РЕПАРАТИВНОГО ОСТЕОГЕНЕЗА В ЭКСПЕРИМЕНТЕArticle: N
    • BMC AnesthesiologyHyperinflation deteriorates arterial oxygenation and lung injury in a rabbit model of ARDS with repeated open endotracheal suctioningPubMed: 25943099
    • J Reprod ImmunolThe immunomodulating effect of seminal plasma on T cellsPubMed: 25799173
    • International Journal of Advanced Research (2016Modulations of serum hepcidin, IL7 and iron status by different exercise regimens in ovarectomized ratsUploads: 605_Ijar-4848
    • TheriogenologyInflammatory cytokines and acute-phase proteins concentrations in the peripheral blood and uterus of cows that developed endometritis during early postpartumPubMed: 25765299
    • Vet Res CommunInflammatory cytokine and acute phase protein concentrations in the peripheral blood and uterine washings of cows with subclinical endometritis in the late postpartum periodPubMed: 25846950
    • Br J NutrEffects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing ratsPubMed: 25745840
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    • Oxidative Medicine and Cellular LongevityBQ123 Stimulates Skeletal Muscle Antioxidant Defense via Nrf2 Activation in LPS-Treated RatsJournals: Omcl
    • Immunol ResConstruction of recombinant Mip-FlaA dominant epitope vaccine against Legionella pneumophila and evaluation of the immunogenicity and protective immunityPubMed: 26607265