Mouse Model for Staphylococcal Scalded Skin Syndrome (SSSS) Mus musculus (Mouse) Disease model

Pemphigus neonatorum; Ritter's disease; Localized bullous impetigo

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by Exfoliative toxin A and B (ETA and ETB)
  • Model Animal StrainsNeonatal Balb/c mouse (SPF), 1 days old
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period1~3 days
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  • Mouse Model for Staphylococcal Scalded Skin Syndrome (SSSS) Packages (Simulation)
  • Mouse Model for Staphylococcal Scalded Skin Syndrome (SSSS) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Exfoliative toxin A, ETA and Exfoliative toxin B, ETB protein were injected subcutaneously at the back of the neck by weight of mice 10ug/g 0.1 mL, newborn mouse after injection get back to the lactation mouse. The changes were observed every hours, and then the mouse were killed after 24h.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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