6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)

IPFK2; PFK2; PFK/FBPase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; Renal carcinoma antigen NY-REN-56

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)
The bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase(PFKFB) regulates the steady-state concentration of fructose-2,6-bisphosphate, a potent activator of a key regulatory enzyme of glycolysis, phosphofructokinase.The predicted PFKFB3 protein, which is 61% similar to human liver PFKFB, contains 529 amino acids and 7 potential phosphorylation sites. Northern blot analysis of first-trimester and term placentas detected a 4.5-kb PFKFB3 transcript.
PFKFB3 is expressed as a 58-kD protein. Molecular sieve analysis confirmed that PFKFB3 is bifunctional, although the phosphatase activity was low due to a mutation in an active site. The kinase activity was upregulated after phosphorylation by protein kinases.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)