F-Box And Leucine Rich Repeat Protein 8 (FBXL8)

FBXL8 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.

The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein.The deduced protein contains an N-terminal F box, followed by 8 tandem leucine-rich repeats.