Isoprenoid Synthase Domain Containing Protein (ISPD)

Nip; Notch1-Induced Protein; 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Synthase Homolog; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein

Isoprenoid Synthase Domain Containing Protein (ISPD)
A hypothetical gene with similarity to the gene of Escherichia coli was cloned from Arabidopsis thaliana cDNA. The ORF of 909 bp specifies a protein of 302 amino acid residues. The cognate chromosomal gene consists of 2,071 bp and comprises 11 introns with a size range of 78–202 bp. A fragment comprising amino acid residues 76–302 was expressed in a recombinant E. coli strain.
Numb and Notch signalling pathways are vitally important in cell fate and differentiation. The outcome of these signalling processes is determined by a delicate balance between opposing effects of Notch and Numb. Imbalance in Numb/Notch regulation was implicated in aberrant differentiation programme and epithelial cancer progression and metastasis.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)