Keratin 38 (KRT38)

KRTHA8; K38; HHA8; HKA8; Keratin,Hair,Acidic 8; Keratin, type I cuticular Ha8

Keratin 38 (KRT38)
KRTHA8 is expressed in the human hair follicle.the deduced KRTHA8 protein, which they called HA8, has 415 amino acids. The KRTHA8 gene contains 7 exons.The hair keratin genes range in size from 4.2 to 7.5 kb, and the genes are separated from each other by 5.5 to 18.4 kb; all are located within about 140 kb. Each gene is transcribed from the 5-prime to 3-prime direction. Based on sequence homologies, the genes can be grouped into 3 subclusters of tandemly arranged genes. The functional hair keratins and hypothetical HAA hair keratin share approximately 81% overall amino acid identity. Due to an almost completely identical head domain, KRTHA7 and KRTHA8 are 92.6% identical. The third subcluster, group C, consists of the structurally less related hair keratins KRTHA2, KRTHA5, and KRTHA6, which share about 70% amino acid identity.

Organism species: Homo sapiens (Human)