2,4-Dienoyl Coenzyme A Reductase 2, Peroxisomal (DECR2)
PDCR; SDR17C1; Short Chain Dehydrogenase/Reductase Family 17C,Member 1; Peroxisomal 2,4-dienoyl-CoA reductase; 2,4-dienoyl-CoA reductase 2
Based on the primary structure of the rat peroxisomal 2,4-dienoyl-CoA reductase, the cDNA of the human counterpart was cloned. It contained an open reading frame of 878 bases encoding a protein of 291 amino acids (calculated molecular mass 30778 Da), being 83% identical to the rat reductase. The gene, encompassing nine exons, is located at chromosome 16p13. Bacterially expressed poly(His)-tagged reductase was active not only towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA. Hence, the reductase does not seem to constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. The reduction of docosaheptaenoyl-CoA, however, was severely decreased in the presence of albumin.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a CLIA Kit for 2,4-Dienoyl Coenzyme A Reductase 2, Peroxisomal (DECR2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for 2,4-Dienoyl Coenzyme A Reductase 2, Peroxisomal (DECR2) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
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- Customized Service n/a Polyclonal Antibody to 2,4-Dienoyl Coenzyme A Reductase 2, Peroxisomal (DECR2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for 2,4-Dienoyl Coenzyme A Reductase 2, Peroxisomal (DECR2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for 2,4-Dienoyl Coenzyme A Reductase 2, Peroxisomal (DECR2) ELISA Kit Customized Service Offer