3-Oxoacid Coenzyme A Transferase 2 (OXCT2)

OXCT2 is a testis-specific succinyl-CoA:3-oxoacid CoA transferase (EC 2.8.3.5), which catalyzes the reversible transfer of CoA from succinyl-CoA to acetoacetate in the first step of ketone body utilization. See also OXCT1.

The deduced 517-amino acid protein contains a predicted hydrophilic bridge region and a conserved active site glutamate in common with OXCT1. OXCT2 shares 75.8% and 74.6% amino acid identity with mouse Oxct2 and human OXCT1, respectively. Northern blot analysis detected a 1.8-kb transcript expressed exclusively in testis. OXCT2 gene lacks an intron, and they identified a nearby nonfunctional pseudogene in which nucleotides 745-762 and 778 are deleted. The entire OXCT2 transcription unit is located within an intron of the BMP8 gene .