5,10-Methenyltetrahydrofolate Synthetase (MTHFS)
5-Formyltetrahydrofolate Cyclo-Ligase
5,10-Methenyltetrahydrofolate synthetase (MTHFS; EC 6.3.3.2) catalyzes the ATP- and Mg(2+)-dependent conversion of 5-formyltetrahydrofolate (5-FTHF) to 5,10-methenyltetrahydrofolate (5,10-MTHF), which is subsequently interconverted into other reduced folates involved in 1-carbon metabolism. It is a 27-kD monomeric protein with a pI of 7.0.The deduced 203-amino acid protein contains a consensus ATP-binding site, a potential Mg(2+)-binding site, a sequence similar to a conserved sequence present in almost all enzymes using 10-FTHF as a substrate, and several consensus phosphorylation sites. The human and rabbit MHTFS proteins are 77% identical. Northern blot analysis of human tissues detected an approximately 0.9-kb MTHFS transcript that was expressed preferentially in liver.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for 5,10-Methenyltetrahydrofolate Synthetase (MTHFS) ELISA Kit Customized Service Offer