5-Hydroxytryptamine Receptor 7 (HTR7)

The receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-HT) The 5-HT₇ receptor is coupled to G_s (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels. This receptor has been a drug development target for the treatment of several clinical disorders. The 5-HT₇ receptor is encoded by the intron containing HTR7 gene, which in humans is transcribed into 3 different splice variants.In humans, the neurotransmitter serotonin (5-HT) plays an important role in various cognitive and behavioral functions. The serotonin receptor encoded by the HTR7 gene belongs to the superfamily of G protein-coupled receptors (GPCRs).