6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)

IPFK2; PFK2; PFK/FBPase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; Renal carcinoma antigen NY-REN-56
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)
The bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase(PFKFB) regulates the steady-state concentration of fructose-2,6-bisphosphate, a potent activator of a key regulatory enzyme of glycolysis, phosphofructokinase.The predicted PFKFB3 protein, which is 61% similar to human liver PFKFB, contains 529 amino acids and 7 potential phosphorylation sites. Northern blot analysis of first-trimester and term placentas detected a 4.5-kb PFKFB3 transcript.
PFKFB3 is expressed as a 58-kD protein. Molecular sieve analysis confirmed that PFKFB3 is bifunctional, although the phosphatase activity was low due to a mutation in an active site. The kinase activity was upregulated after phosphorylation by protein kinases.
Organism species: Homo sapiens (Human)
  • Protein RPD401Hu01Recombinant 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • AntibodyPAD401Hu01Polyclonal Antibody to 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • AntibodyMAD401Hu21Monoclonal Antibody to 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • Assay KitSED401HuELISA Kit for 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • Assay KitSCD401HuCLIA Kit for 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPD401Mu01Recombinant 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • AntibodyPAD401Mu01Polyclonal Antibody to 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • AntibodyMAD401Mu21Monoclonal Antibody to 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • Assay KitSED401MuELISA Kit for 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • Assay KitSCD401MuCLIA Kit for 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPD401Ra01Recombinant 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • AntibodyPAD401Ra01Polyclonal Antibody to 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • AntibodyMAD401Ra21Monoclonal Antibody to 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • Assay KitSED401RaELISA Kit for 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
  • Assay KitSCD401RaCLIA Kit for 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3)Customize
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