A Disintegrin And Metalloprotease 11 (ADAM11)

ADAM11 encodes a member of the ADAM (a disintegrin and metalloprotease) protein family.This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.

ADAM11encoded a 524-amino acid metalloproteinase-like, disintegrin-like, and cysteine-rich (MDC) protein with sequence similarity to members of the snake-venom metalloprotease/disintegrin family and guinea-pig sperm-surface protein PH-30. These proteins have been implicated in cell-cell or cell-extracellular matrix interactions. Rearrangements in both tumors involved multiple exons and disrupted the coding region of the gene.