A Disintegrin And Metalloprotease 23 (ADAM23)
MDC3; Metalloproteinase Like,Disintegrin Like,And Cysteine Rich Protein 3; Disintegrin and metalloproteinase domain-containing protein 23
The cellular disintegrins, also known as ADAM and MDC proteins, are a class of potential cell adhesion molecules. By searching an EST database for sequences related to MDC, Sagane et al. (1998) identified a partial MDC3 cDNA. They screened a human brain cDNA library and used 3-prime RACE to clone additional cDNAs corresponding to the entire MDC3 coding region. The predicted 832-amino acid protein contains the typical cellular disintegrin domains. However, the zinc-binding motif, which is critical for proteinase activity, is disrupted in MDC3 as well as the other MDC proteins. MDC3 shares approximately 52% sequence similarity with MDC and MDC2. Northern blot analysis revealed that MDC3 was expressed predominantly in brain as several transcripts ranging in size from 3.5 to 7 kb.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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