A Kinase Anchor Protein 1 (AKAP1)

The A kinase anchor protein 1, mitochondrial binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.

PP1 and RNA binding to this same site was mutually exclusive and controlled through a novel, phosphorylation-dependent mechanism. A collapse of the mitochondrial network was observed upon introduction of RNA-binding deficient mutants of AKAP149, pointing to the importance of RNA tethering to the mitochondrial membrane by AKAP149 for mitochondrial distribution.