ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2)
BIG2; ARFGEP2; Brefeldin A-Inhibited; Brefeldin A-inhibited guanine nucleotide-exchange protein 2
ARFGEF2 encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.BIG2 encodes a protein of 1,785 amino acids containing a Sec7 domain characteristic of other ADP ribosylation factor (ARF) guanine nucleotide exchange proteins. BIG2 shares 74% overall amino acid identity with BIG1 and 90% identity within the Sec7 domain. BIG2 protein is required for vesicle and membrane trafficking from the trans-Golgi network. Inhibition of BIG2 by BFA, or by a dominant-negative ARFGEF2 cDNA, decreased cell proliferation in vitro, suggesting a cell-autonomous regulation of neural expansion.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) ELISA Kit Customized Service Offer