ADP Ribosylhydrolase Like Protein 1 (ADPRHL1)

ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction . ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases, such as ART1, transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases reverse the reaction

By database analysis and PCR of brain cDNA libraries, Oka et al. (2006) cloned mouse and human ADPRHL1, which they called ARH2. The deduced human protein contains 354 amino acids and is 85% identical to its mouse homolog. By genomic sequence analysis, Glowacki et al. (2002) mapped the ADPRHL1 gene to chromosome 13q31.