ADP Ribosyltransferase 2 (ART2)

ARTC2; Art2b; Rt6-b; T-cell ecto-ADP-ribosyltransferase 2; ADP-ribosyltransferase C2 and C3 toxin-like 2; Alloantigen Rt6.2; T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2

ADP Ribosyltransferase 2 (ART2)
NAD functions in multiple aspects of cellular metabolism and signaling through enzymes that covalently transfer ADP-ribose from NAD to acceptor proteins, thereby altering their function. NAD is a substrate for two enzyme families, mono-ADP-ribosyltransferases and poly(ADP-ribose) polymerases, that covalently transfer an ADP-ribose monomer or polymer, respectively, to acceptor proteins. ART2, a mART, is a phenotypic marker of immunoregulatory cells found on the surface of T lymphocytes, including intestinal intraepithelial lymphocytes. Endogenous ART2 on IELs undergoes multimeric auto-ADP-ribosylation more efficiently than ART2 on peripheral T cells, suggesting that these distinct lymphocyte populations differ in their ART2 surface topology. Furthermore, ART2.2 IELs are more resistant to NAD-induced cell death than ART2.1 IELs that do not have multimeric auto-ADP-ribosylation activity.

Organism species: Rattus norvegicus (Rat)