AT-Rich Interactive Domain Containing Protein 2 (ARID2)

ARID2 is a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors.RT-PCR ELISA detected ARID2 expression in all tissues and specific brain regions examined, with highest expression in ovary and lowest expression in spinal cord.The human and Drosophila proteins contain an N-terminal ARID domain, followed by several LLxxLL motifs and C-terminal canonical and variant C2H2-type zinc finger motifs.

ARID2 is an integral component of PBAF. ARID2 interacted directly with BAF180 in the absence of DNA. However, ARID2 was able to form a complex in cells lacking BAF180, and suppression of ARID2 by small interfering RNA in these cells reduced both basal and IFN-alpha-induced IFITM1 expression.