ATP Binding Cassette Transporter G6 (ABCG6)
WBC6; AtWBC6; AtABCG6; White-brown complex homolog protein 6
ATP-binding cassette transporters constitute the biggest family of membrane proteins involved in drug resistance and other biological activities. Resistance of leishmanial parasites to therapeutic drugs continues to escalate in developing countries and in many instances it is due to overexpressed ABC efflux pumps. Progressively adapted camptothecin resistant parasites show overexpression of a novel ABC transporter, which was classified as ABCG6. Transfection and overexpression of LdABCG6 in wild type parasites, shows its localization primarily in the plasma membrane and flagellar pocket region. Overexpressed LdABCG6 confers substantial CPT resistance to the parasites by rapid drug efflux. Various inhibitors have been tested for their ability to revert the CPT-resistant phenotype to specifically understand the inhibition of LdABCG6 transporter.
Organism species: Spinacia oleracea (Spinach)
- Customized Service n/a Recombinant ATP Binding Cassette Transporter G6 (ABCG6) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to ATP Binding Cassette Transporter G6 (ABCG6) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to ATP Binding Cassette Transporter G6 (ABCG6) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for ATP Binding Cassette Transporter G6 (ABCG6) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for ATP Binding Cassette Transporter G6 (ABCG6) ELISA Kit Customized Service Offer