ATP/GTP Binding Protein Like Protein 2 (AGBL2)

AGBL2, Belongs to the peptidase M14 family. may play a role in the processing of tubulin. RARRES1 interacts with and regulates the activity of a novel cytosolic carboxypeptidase (AGBL2) that detyrosinates the C-terminal EEY-regions of alpha-tubulin and EB1, a protein involved in microtubule stability. RARRES1 is a Golgi-associated transmembrane protein that is transported to the cleavage furrow and midbody in dividing cells.

Depletion of RARRES1 increased the incidence of multinucleated cells and impedes cell motility. This data points to a role for RARRES1, AGBL2, EB1 and the microtubule tyrosination cycle in cytokinesis, tumorigenesis and stem cell lineage specification and identify a novel area for intervention.