ATPase Class I Type 8B2 (ATP8B2)

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified.

ATP8B2 is 53% identical to FIC1 (ATP8B1), which is associated with cholestasis. RT-PCR analysis detected wide expression, with highest levels in amygdala, followed by cerebellum, caudate nucleus, subthalamic nucleus, ovary, whole brain, and kidney.