ATPase Class V Type 10A (ATP10A)

ATP10A belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'.

Nagase et al. (1998) isolated a partial cDNA from brain encoding ATP10C, which they called KIAA0566. Based on homology analysis, they predicted that ATP10C is a probable calcium-transporting ATPase. RT-PCR analysis detected wide expression, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary, and small intestine.