ATPase Class VI Type 11C (ATP11C)

The deduced 1,132-amino acid protein has a calculated molecular mass of 130 kD. By searching EST databases, Nesbit et al. (2004) identified mouse and human ATP11C cDNAs with alternate first exons that encode deduced 1,128-amino acid proteins with apparent molecular masses of 129 kD. The mouse and human proteins share 94.8% amino acid identity. Using RT-PCR, Nesbit et al. (2004) also identified mouse and human ATP11C variants in which alternative splicing of exon 29 results in proteins with different C termini. Northern blot analysis of several human tissues detected a 7.4-kb transcript that was expressed ubiquitously and a minor 7.3-kb transcript that was expressed in some tissues, including liver and pancreas.ATP11C gene contains 31 exons, including the alternate first exons 1a and 1b, and spans more than 211 kb.