ATPase Type 13A1 (ATP13A1)

ATP13A1 belongs to the cation transport ATPase (P type) family. Type V subfamily. There are three named isoforms produced by alternative splicing. ATPases are membrane-bound ion channels that couple ion movement through a membrane with the synthesis or hydrolysis of a nucleotide, usually ATP. Different forms of membrane-associated ATPases have evolved over time to meet specific demands of cells. These ATPases have been classified as F-, V-, A-, P- and E-ATPases based on functional differences. They all catalyse the reaction of ATP synthesis and/or hydrolysis. The driving force for the synthesis of ATP is the H⁺ gradient, while during ATP hydrolysis the energy from breaking the ATP phosphodiester bond is the driving force for creating an ion gradient.