Axis Inhibition Protein 2 (AXIN2)
Axil; Conductin; Axin Related Protein; Axin-like protein
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC192Hu01 Recombinant Axis Inhibition Protein 2 (AXIN2) In Stock
- Polyclonal antibody PAC192Hu01 Polyclonal Antibody to Axis Inhibition Protein 2 (AXIN2) In Stock
- Monoclonal antibody MAC192Hu22 Monoclonal Antibody to Axis Inhibition Protein 2 (AXIN2) In Stock
- Monoclonal antibody MAC192Hu21 Monoclonal Antibody to Axis Inhibition Protein 2 (AXIN2) In Stock
- Sandwich ELISA SEC192Hu ELISA Kit for Axis Inhibition Protein 2 (AXIN2) In Stock
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Axis Inhibition Protein 2 (AXIN2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Axis Inhibition Protein 2 (AXIN2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Axis Inhibition Protein 2 (AXIN2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Axis Inhibition Protein 2 (AXIN2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Axis Inhibition Protein 2 (AXIN2) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Axis Inhibition Protein 2 (AXIN2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Axis Inhibition Protein 2 (AXIN2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Axis Inhibition Protein 2 (AXIN2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Axis Inhibition Protein 2 (AXIN2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Axis Inhibition Protein 2 (AXIN2) ELISA Kit Customized Service Offer