Abnormal Spindle Like Microcephaly Associated Protein (ASPM)
ASP; MCPH5; Calmbp1; Abnormal Spindle Protein Homolog; Asp Homolog ; Microcephaly,Primary Autosomal Recessive 5
ASPM is located on chromosome 1, band q31 (1q31). Defective forms of the ASPM gene are associated with autosomal recessive primary microcephaly.
"ASPM" is an acronym for "Abnormal Spindle-like, Microcephaly-associated", which reflects its being an ortholog to the Drosophila melanogaster "abnormal spindle" (asp) gene. The expressed protein product of the asp gene is essential for normal mitotic spindle function in embryonic neuroblasts.The mouse gene, Aspm, is expressed in the primary sites of prenatal cerebral cortical neurogenesis. The difference between Aspm and ASPM is a single, large insertion coding for so-called IQ domains. Studies in mice also suggest a role of the expressed Aspm gene product in mitotic spindle regulation.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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