Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1)
Pa; Pr; Db-s; PRP-1/PRP-2; Proline-Rich Protein HaeIII 1; Parotid double-band protein; Parotid isoelectric focusing variant protein; Parotid acidic protein; Parotid proline-rich 1/2
According to the hypothesis of Maeda, the 3 acidic PRPs, Db, Pa, and PIF, are coded for by alleles at a single locus rather than by 3 discrete loci. The hypothesis is based on DNA studies which suggest that 6 loci control the synthesis of the PRPs. Genes at 2 of these loci, PRH1 and PRH2 (so named because they contain repeated cleavage sites for the restriction enzyme HaeIII), code for the acidic PRPs. Genes at the remaining 4 loci (PRB1, PRB2, PRB3, and PRB4) contain regions that strongly hybridize to a probe with repeated BstNI sites; they probably code for the basic and glycosylated PRPs. This hypothesis of 6 loci forming 2 gene subfamilies contrasts with that based on protein polymorphisms in families that suggest 13 loci with 11 common null alleles.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) Polyclonal Antibody Customized Service Offer
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