Actin Binding LIM Protein 2 (ABLIM2)

ABLIM2 gene contains 20 exons and spans about 194 kb. The 5-prime region contains numerous transcription factor binding sites, including 3 for NRSF (REST) and 5 for WT1.

The deduced proteins contain 649 and 559 amino acids. Northern blot analysis detected highest expression in skeletal muscle and lower expression in brain, spleen, and kidney. Heart and skeletal muscle expressed both ABLIM2 variants. In situ hybridization of embryonic day-15.5 mouse showed high Ablim2 expression in skeletal muscle and weaker expression in the central nervous system. Ablim2 and Ablim3 showed different expression patterns in regions of adult mouse brain, including hippocampus and cerebellum.