Actin Binding Rho Activating Protein (ABRA)
STARS; Striated muscle activator of Rho-dependent signaling
STARS directly associates with actin. Deletion mutant experiments revealed that STARS requires 2 separate but codependent regions (amino acids 234-279 and 346-375) to bind to actin. STARS localized to the I-band of the sarcomere in rat primary cardiomyocytes and to actin stress fibers in transfected cells. In situ hybridization experiments showed that STARS was expressed specifically in the primitive heart tube of mice at embryonic day 8.75 and also in skeletal muscle by E10.5.the conserved C-terminal region of STARS was necessary and sufficient to stimulate expression from the SM22 promoter, which contains 2 serum response factor (SRF)-binding sites (CArG boxes).the transcriptional activation by STARS is mediated in large part by the cytoskeleton but also by a Rho-dependent mechanism.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Actin Binding Rho Activating Protein (ABRA) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Actin Binding Rho Activating Protein (ABRA) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Actin Binding Rho Activating Protein (ABRA) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Actin Binding Rho Activating Protein (ABRA) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Actin Binding Rho Activating Protein (ABRA) ELISA Kit Customized Service Offer