Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1)
ASC1p50; ASC-1 complex subunit p50; Trip4 complex subunit p50
Human activating signal cointegrator 1 (hASC-1) was originally isolated as a transcriptional coactivator of nuclear receptors. ASC-1 exists as a steady-state complex associated with three polypeptides, P200, P100, and P50, in HeLa nuclei; stimulates transactivation by serum response factor (SRF), activating protein 1 (AP-1), and nuclear factor kappaB (NF-kappaB) through direct binding to SRF, c-Jun, p50, and p65; and relieves the previously described transrepression between nuclear receptors and either AP-1 or NF-kappaB.
In addition, neutralization of endogenous P50 by single-cell microinjection of a P50 antibody inhibits AP-1 transactivation; the inhibition is relieved by coexpression of wild-type P50, but not of P50DeltaKH, a mutant form that does not interact with P200.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1) ELISA Kit Customized Service Offer