Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2)
ASC1p100; ASC 1 Complex Subunit P100; Trip4 complex subunit p100
ASC-1 exists as a steady-state complex associated with three polypeptides, P200, P100, and P50, in HeLa nuclei; stimulates transactivation by serum response factor (SRF), activating protein 1 (AP-1), and nuclear factor kappaB (NF-kappaB) through direct binding to SRF, c-Jun, p50, and p65; and relieves the previously described transrepression between nuclear receptors and either AP-1 or NF-kappaB.
Interestingly, ectopic expression of Caenorhabditis elegans ASC-1 (ceASC-1), an ASC-1 homologue that binds P200 and P100, like hASC-1, while weakly interacting only with p65, in HeLa cells appears to replace endogenous hASC-1 from the hASC-1 complex and exerts potent dominant-negative effects on AP-1, NF-kappaB, and SRF transactivation.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2) ELISA Kit Customized Service Offer