Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2)
MCAF2; Mbd1-Containing Chromatin-Associated Factor 2
Conserved domains 1 and 2 of MCAF1 and MCAF2 share 27% and 56% amino acid identity, respectively. Database analysis revealed that domain 2 shows highest conservation between species. Western blot analysis of several human cell lines detected variable ATF71IP2 expression at an apparent molecular mass of 100 kD. Fluorescence-tagged MCAF1 and MCAF2 colocalized with MBD1 at nuclear foci.Immunoprecipitation analysis of K562 human erythroleukemia cells revealed that MCAF1 showed higher affinity for SETDB1 than SP1, whereas MCAF2 showed higher affinity for SP1 than SETDB1. Both MCAF proteins were also detected in the same immunoprecipitates. Both MCAF1 and MCAF2 increased transcription of a reporter gene activated by SP1, and the TRD of MBD1 moderately repressed transcription in the presence of either MCAF1 or MCAF2
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2) ELISA Kit Customized Service Offer