Activating Transcription Factor 5 (ATF5)

First described by Nishizawa and Nagata, ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.ATF5 transcripts and protein are expressed in a wide variety of tissues, particularly high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at the transcriptional and translational level.Sequence analysis predicted that the 282-amino acid protein, which is 57% identical to CREB2 (ATF2) in the bZIP domain, contains 2 N-terminal consensus MAP kinase phosphorylation sites. Mutation analysis showed that the GABBR1-ATF5 interaction occurs between the C-terminal coiled-coil domain of GABBR1 and the bZIP domain of ATF5.