Active BCR Related Gene (ABR)
MDB; Active breakpoint cluster region-related protein
ABR encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis, suggesting that Rho-related GTPases help coordinate motor skills and balance. Alternatively spliced transcript variants that encode different isoforms have been reported for this gene.
A cosmid contig constructed in this region was used to demonstrate by fluorescence in situ hybridization that the 5-prime to 3-prime transcriptional orientation of the ABR gene is toward the telomere.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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