Acyl Coenzyme A Dehydrogenase Family, Member 11 (ACAD11)

ACAD11 belongs to the acyl-CoA dehydrogenase (ACADs) family. ACADs are a group of mitochondrial enzymes involved in the metabolism of fatty acids or branched-chain amino acids. ACAD11 is a bifunctional protein consisting of an aminoglycoside phosphotransferase-domain and an acyl-CoA dehydrogenase domain. There are 3 named isoforms.

Acyl-CoA dehydrogenases are a class of enzymes that function to catalyze the initial step in each cycle of fatty acid β -oxidation in the mitochondria of cells. FAD is a required co-factor in the mechanism in order for the enzyme to bind to its appropriate substrate.Acyl-CoA dehydrogenases are an important class of enzymes in mammalian cells because of their role in metabolizing fatty acids present in ingested food materials.