Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2)
DIP13B; DCC-interacting protein 13-beta
APPL2 encodes a 541-amino acid protein. Northern blot analysis detected a 4-kb transcript in several tissues, including kidney, brain, heart, and skeletal muscle. The FLJ10659 transcript was expressed in all central nervous system samples.
This pathway operated via APPL1 and APPL2, 2 RAB5 effectors that reside on a subpopulation of endosomes. In response to extracellular stimuli such as EGF and oxidative stress, APPL1 translocated from the membranes to the nucleus, where it interacted with the nucleosome remodeling and histone deacetylase (NURD) multiprotein complex, a regulator of chromatin structure and gene expression. Both APPL1 and APPL2 were essential for cell proliferation, and their function required RAB5 binding.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 2 (APPL2) ELISA Kit Customized Service Offer