Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 1 (APPL1)
APPL; DIP13A; DIP13alpha; DCC-interacting protein 13-alpha
APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. The PH domain of APPL shows similarity to those found in GTPase-activating proteins such as oligophrenin-1, whereas its PTB domain exhibits homology with CED-6, an adaptor protein that promotes engulfment of apoptotic cells, and IB1, a transactivator of the GLUT2 gene. APPL is highly expressed in skeletal muscle, heart, ovary, and pancreas, tissues in which AKT2 mRNA is abundant.
Organism species: Homo sapiens (Human)
- Recombinant protein RPL208Hu01 Recombinant Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 1 (APPL1) In Stock
- Polyclonal antibody PAL208Hu01 Polyclonal Antibody to Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 1 (APPL1) In Stock
- Sandwich ELISA SEL208Hu ELISA Kit for Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 1 (APPL1) In Stock
Organism species: Mus musculus (Mouse)
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