Adenosine Deaminase Like Protein (ADAL)

ADAL, Belongs to the adenosine and AMP deaminases family. Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism. Adenosine Deaminase (ADA) is a cytosolic enzyme, which has been the object of considerable interest, mainly because in human a congenital defect in the enzyme causes severe combined immunodeficiency disease (SCID). ADA participates in the purine metabolism where it degrades either adenosine or 2’-deoxyadenosine producing inosine or 2’- deoxyinosine, respectively. Further metabolisation of these deaminated nucleosides leads to hypoxanthine, which can be either transformed into uric acid by xanthine oxidase or salvaged into mononucleotides by the action of hypoxanthine-guanine phosphoribosyl-transferase.