Adenylate Kinase 5 (AK5)

AK5 encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species.

It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. The protein contains a nucleoside triphosphate binding glycine-rich region, a nucleoside monophosphate-binding site, and the lid domain that closes over the substrate upon binding. It shares 58%, 26%, and 25% structural identity with AK1 , AK2 , and AK3 , respectively.