Ajuba (JUB)

JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.

The 5-prime UTR contains a GC-rich region, and the deduced protein contains 547 amino acids. The N-terminal two-thirds of the protein is rich in glycine and proline, and the C terminus contains 3 tandemly arrayed LIM domains most homologous to group-3 LIM proteins. Ajuba also has 2 stretches of proline-rich SH3 recognition motifs and a nuclear export signal. In adult mouse tissues, Ajuba was expressed in skin, brain, and genitourinary organs. Epitope-tagged Ajuba localized to the cytosol of transfected mouse fibroblasts, with trace amounts at the cell surface.