Aldo Keto Reductase Family 1, Member E2 (AKR1E2)

AKR1E2 belongs to the aldo/keto reductase family. Out of the remaining 5 genes, one belongs to the AKR1E family and encodes a protein named human testis AKR. This gene is listed as AKR1CL2 and should be renamed AKR1E2, in accordance with to the nomenclature of the AKR superfamily. The Aldo-Keto Reductase (AKR) superfamily comprises of several enzymes that catalyze redox transformations involved in biosynthesis, intermediary metabolism and detoxification. Substrates of the family include glucose, steroids, glycosylation end products, lipid peroxidation products, and environmental pollutants. These proteins adopt a (β/α)₈ barrel structural motif interrupted by a number of extraneous loops and helixes that vary between proteins and bring structural identity to individual families.