AlkB, Alkylation Repair Homolog 2 (ALKBH2)
ABH2; Oxy DC1; DNA oxidative demethylase ALKBH2; Alkylated DNA repair protein alkB homolog; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine.The deduced protein shares 30.8% amino acid identity over the core region with E. coli AlkB and shares similarity to alpha-ketoglutarate/Fe(II)-dependent dioxygenases in the C-terminal region. Northern blot analysis detected ALKBH2 expression in all tissues examined, as well as several carcinoma cell lines, with highest expression in liver and bladder. Immunofluorescence studies localized ALKBH2 to the nucleus with a diffuse pattern throughout the nucleoplasm and accumulation in the nucleoli.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 2 (ALKBH2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for AlkB, Alkylation Repair Homolog 2 (ALKBH2) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant AlkB, Alkylation Repair Homolog 2 (ALKBH2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 2 (ALKBH2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 2 (ALKBH2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for AlkB, Alkylation Repair Homolog 2 (ALKBH2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for AlkB, Alkylation Repair Homolog 2 (ALKBH2) ELISA Kit Customized Service Offer