Allograft Inflammatory Factor 1 Like Protein (AIF1L)

AIF1L, also known as allograft inflammatory factor 1-like, is a cytoplasmic, cytokine-induced, calcium-binding protein first discovered in rat cardiac allografts with chronic rejection. This protein is a marker of human microglia and is expressed by macrophages in injured skeletal muscle and regulates reduced proliferation and differentiation of satellite cells.

AIF1L, Contains 2 EF-hand domains. Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function. Allograft inflammatory factor-1 (AIF-1) is an evolutionarily conserved, inflammatory protein produced by activated macrophages during chronic transplant rejection and in inflammatory brain lesions.