Amidohydrolase Domain Containing Protein 2 (AMDHD2)

AMDHD2 belongs to the nagA family. It catalyzes N-acetyl-D-glucosamine 6-phosphate and H₂O to D-glucosamine 6-phosphate and acetate. There are two named isoforms.

Amidohydrolases are a diverse superfamily of enzymes which catalyse the hydrolysis of amide or amine bonds in a large number of different substrates including urea, cytosine, AMP, formylmethanofuran, etc. Also included in this superfamily are the phopshotriesterase enzymes, which hydrolyse P-O bonds. Members participate in a large number of processes including nucleotide metabolism, detoxification and neuronal development. They use a variety of divalent metal cofactors for catalysis: for example adenosine deaminase binds a single zinc ion, phopsphotriesterase binds two, while urease binds nickel.