Amiloride Sensitive Sodium Channel Subunit Delta (SCNN1d)
ENaCd; ENaCdelta; SCNED; dNaCh; Sodium Channel,Nonvoltage-Gated 1,Delta; Epithelial Na(+) channel subunit delta; Nonvoltage-gated sodium channel 1 subunit delta
Amiloride-sensitive sodium channel subunit delta is a protein encoded by the SCNN1D gene.The epithelial sodium channel (short: ENaC, also: sodium channel non-neuronal 1 (SCNN1) or amiloride sensitive sodium channel (ASSC)) is a membrane-bound ion-channel that is permeable for Li+-ions, protons and especially Na+-ions. It is a constitutively active ion-channel. It is arguably the most selective ion channel.
The apical membrane of many tight epithelia contains sodium channels that are primarily characterised by their high affinity to the diuretic blocker amiloride. These channels mediate the first step of active sodium reabsorption essential for the maintenance of body salt and water homeostasis.
Organism species: Homo sapiens (Human)
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