Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 2 (AIMP2)

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown.The p38 protein is a moderately hydrophobic protein, displays a putative leucine-zipper motif, and shares a sequence pattern with protein domains that are involved in protein-protein interactions. p38 was found to associate with itself to form a dimer, but also with p43, with the class I tRNA synthetases arginyl-tRNA synthetase (ArgRS) and GlnRS, with the class II synthetases AspRS and LysRS, and with the bifunctional GluProRS.