Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 4 (ALS2CR4)
TMEM237; Transmembrane protein 237
Als2cr4 is a novel protein, with a probable tetraspanin-like membrane structure, that is localized in photoreceptors and in the postsynaptic outer plexiform layer and that interacts with cytoskeletal proteins. Als2cr4 may be involved in membrane transport between the photoreceptor inner and outer segments and may be a key component in maintaining the structural integrity of the outer segment. Als2cr4 is a 45-kDa insoluble protein, highly enriched in retina, and localizes to photoreceptor outer segments, ciliary complex, and horizontal cells in the outer plexiform layer. Immunoelectron microscopy for Als2cr4 verified its expression in the discs of photoreceptor outer segments. Immunoprecipitation and mass spectroscopy identified eight potential interacting partners: vimentin, actin, myosin Va, myosin VI, myosin X, myosin XIV, kinesin 1, Als2cr4, and lamin B-1.
Organism species: Homo sapiens (Human)
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 4 (ALS2CR4) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 4 (ALS2CR4) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 4 (ALS2CR4) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Amyotrophic Lateral Sclerosis 2 Chromosome Region, Candidate 4 (ALS2CR4) CLIA Kit Customized Service Offer
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